Markers of inflammation, cardiac regulation

New research linking air pollution data from federal monitors in the Sacramento area of ​​California, including during large fires, shows the harmful effects of exposure to air pollution in children, according to a new study from the University of California at Davis.

Samples of blood show that children have elevated markers of inflammation, such as interleukin 6, if they were exposed to higher air pollution. Additionally, higher air pollution was linked to lower cardiac autonomic regulation in children, which impacts how fast the heart beats and how hard it pumps, according to the study.

In the study, published August 3 in the journal New Instructions for Youngster and Adolescent Study, researchers examined blood samples from over 100 healthy children aged 9 to 11 years in the Sacramento area, where pollutants near their homes have been recorded by the defense of the environment. Agency. The study was authored by Anna M. Parenteau, Ph.D. student, and Camelia E. Hostinar, associate professor, both from the Department of Psychology at UC Davis. The work took place at UC Davis.

These findings are important because exposure to pollutants released during wildfires has been associated with numerous negative health effects children, whose bodies and organs are smaller than adults, including asthma and decreased lung function, as well as neurodevelopmental effects such as attention deficit hyperactivity disorder, autism and deficits in academic performance and memory, the researchers said.

Looked at the particles

Researchers looked at data on EPA fine particulate matter (PM2.5) – or fine particles that can enter the lungs and pass through the bloodstream – and found that children’s blood contained markers systemic inflammation. Additionally, PM2.5, which the EPA refers to particles measuring 2.5 micrometers or less, was linked to lower cardiac autonomic regulation as assessed using an electrocardiogram. Specifically, the researchers used data files maintained by the EPA, which contain daily air quality summary information from every outdoor monitor in the country.

A total of 27 of the children studied had inflammation markers in their blood recorded during large fires when their neighborhoods recorded significant levels of PM2.5 in their blood. ‘air. These times when the fires were burning included the Mendocino Complex Fire in 2018, which was active at approximately 11 miles from the lab where the blood was drawn. The results were similar to those found in an earlier study, in which the blood of young primates was collected by UC Davis researchers after large forest fires.

this study further demonstrates the immediate consequences of exposure to air pollution, which may increase the risk of future diseases,” Parenteau said. In addition, Mr. Parenteau added: “As climate change continues to have an influence on children and families, it is paramount to understand the impact of environmental contaminants such as air pollution on the physiology of children.”

Previous studies in children have shown significant associations between ambient air pollution and allergic sensitization, respiratory symptoms, and ultra-structural and cellular changes in their lungs and airways, researchers have reported.

Researchers have found that children may be particularly susceptible to the effects of air pollution, given that, compared to adults, they have a higher intake of contaminants and a larger lung area compared to their body weight.

The continuation of developmental research on contamin Environmental scientists can sound the alarm about the effects of air pollution and inform policy changes that could benefit people’s health in the very long term, the researchers concluded.

Co-authors, all of whom graduated and completed their research at UC Davis during the study, include researchers from the University of Trier, Germany UC San Francisco Whitman College and the University of Denver.

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